Neurons are now known to produce a variety of types of chemical transmitters. Classical transmitters are stored within synaptic vesicles which undergo synaptic exocytosis in association with presynaptic thickenings. The larger, dense‐cored secretory granules present in most neurons contain neuropeptides and mainly discharge their contents at morphologically undifferentiated (i.e.nonsynaptic) sites. The synaptic character of vesicle discharge enables transmitters to exercise a highly focal action, whereas nonsynaptic release probably relates to the slow rate of degradation of many neuropeptides and their consequent (...) widespread diffusion and sphere of action. However, one variant of the basic pattern, involving the restriction of granule discharge to areas of the terminal plasmalemma situated adjacent to the postsynaptic cells (i.e. a parasynaptic configuration), enables a degree of targeted peptide discharge to be achieved. The diversity of patterns of neural exocytosis adds a further dimension to the complexity of nervous function. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Feminism and Classics:Framing the Research AgendaBarbara K. GoldA landmark conference on "Feminism and Classics: Framing the Research Agenda" was held at Princeton University on November 7-10, 1996; the coorganizers were Janet M. Martin (Princeton University) and Judith P. Hallett (University of Maryland). This conference is the second in a series of more-or-less triennial meetings devoted to feminist research in various areas of classical studies. The first of these conferences (...) ("Feminism and Classics I") was held at the University of Cincinnati in 1992 and was codirected by Kathryn J. Gutzwiller and Ann N. Michelini (both of the University of Cincinnati; for a review of this conference see Clara Hardy and Kirk Ormand, BMCR 4.2 [1993] 135-41).The goals of the Princeton conference were several:mdash To address the evidential deficiencies of the traditional classical literary canon-by examining new kinds of sources and evidence, particularly nonliterary texts and material culture; and by giving increased attention to the ancient Near East and Africa (especially Egypt) as well as to post-classical Greek and Latin texts;mdash To address the methodological inadequacies of traditional historical and philological approaches-by applying the new literary and textual criticism and theory to the traditional classical literary canon as well as to nonliterary and postclassical texts; by adopting comparative approaches to the study of ancient sexuality and gender; and by considering women (in addition to men) as agents in the transmission of the classical tradition;mdash To clarify, illuminate, and evaluate the relations between classical scholarship and the politics of social change-by defining the actual and potential relations among feminist studies, gender studies, and women's studies, and the relation of classical studies to each; by examining the variety of relations that feminist and other scholarship can have to the politics of social change; and by addressing the role of theory in feminist scholarship in classics.The conference was divided into four plenary sessions, each one devoted to a core area of feminist scholarly research in classics: The Historical Recovery of Ancient Women (Speakers: Shelby Brown, UCLA [End Page 328] and Alan Shapiro, University of Canterbury, New Zealand; Discussants: Barry S. Strauss, Cornell University and Sandra R. Joshel, New England Conservatory of Music); Women and the Classical Tradition (Speakers: Joan M. Ferrante, Columbia University and Shelley P. Haley, Hamilton College; Discussants: Diana Robin, University of New Mexico and Judith P. Hallett, University of Maryland); Feminist Literary Studies and the Construction of Sexuality and Gender in the Ancient World (Speakers: David Konstan, Brown University and Barbara K. Gold, Hamilton College; Discussants: Ellen Oliensis, Yale University and Ruth Webb, Princeton University); Feminism and Classics in the Next Century: Feminist Studies, Gender Studies, Women's Studies (Speakers: Peter W. Rose, Miami University of Ohio and Nancy F. Partner, McGill University; Discussants: Sarah B. Pomeroy, Hunter College and CUNY and Amy Richlin, University of Southern California).In addition to the four plenary sessions, there was a rich variety of discussion and presentation in other formats: opening and closing roundtables (including, in addition to some of the speakers and organizers, Nancy Sorkin Rabinowitz, Hamilton College, Barbara M. McManus, College of New Rochelle, Bella Zweig, University of Arizona, Kathryn J. Gutzwiller, and Ann N. Michelini, both of the University of Cincinnati); the keynote address by Ernestine Friedl, Duke University; and sixteen interactive workshops, which followed up on the topics of the plenary sessions. These covered topics as broad as "Reading Gender in Epigraphical Text and Context" (Susan Guettel Cole), "The Classical World in Twentieth-Century Historical Fiction by Women" (Sheila Murnaghan and Deborah H. Roberts), "Feminist Theory/Queer Theory" (Kirk Ormand and Rabinowitz), "Politics, Pedagogy, and the Future of Gender Studies" (Mary Whitlock Blundell, Jeffrey S. Carnes, and John T. Kirby), and "Feminist Anthropology and Feminist Work in Classics" (Deborah Lyons).The conference was one of several events celebrating the 250th anniversary of Princeton University. In certain respects it carried on the work of the 1917 Princeton conference organized by Dean Andrew Fleming West. Entitled "Value of the Classics," the 1917 conference was also in its own way interdisciplinary, documenting the impact of classics on such fields as medicine, law, economics, sociology, and public... (shrink)

[Open access] In this book symposium the author takes up questions from phenomenology, hermeneutics, ethical theory, and intellectual history raised by a group of scholarly interlocutors from a range of backgrounds. In the course of engaging with these issues, he discusses, inter alia, McDowell’s realism, Jonathon Lear’s work on the end of a world, Michael Oakeshott’s view of selfhood, Heidegger’s conception of Jemeinigkeit, Uexküll’s notion of Umwelt, and Gadamer’s hermeneutic conception of truth.

Evolution is frequently concentrated in bursts of rapid morphological change and speciation followed by long‐term stasis. We propose that this pattern of punctuated equilibria results from an evolutionary tug‐of‐war between host genomes and transposable elements (TEs) mediated through the epigenome. According to this hypothesis, epigenetic regulatory mechanisms (RNA interference, DNA methylation and histone modifications) maintain stasis by suppressing TE mobilization. However, physiological stress, induced by climate change or invasion of new habitats, disrupts epigenetic regulation and unleashes TEs. With their capacity (...) to drive non‐adaptive host evolution, mobilized TEs can restructure the genome and displace populations from adaptive peaks, thus providing an escape from stasis and generating genetic innovations required for rapid diversification. This “epi‐transposon hypothesis” can not only explain macroevolutionary tempo and mode, but may also resolve other long‐standing controversies, such as Wright's shifting balance theory, Mayr's peripheral isolates model, and McClintock's view of genome restructuring as an adaptive response to challenge. (shrink)

In birds and frogs, species pairs retain the capacity to produce viable hybrids for tens of millions of years, an order of magnitude longer than mammals. What accounts for these differences in relative rates of pre- and postzygotic isolation? We propose that reproductive mode is a critically important but previously overlooked factor in the speciation process. Viviparity creates a post-fertilization arena for genomic conflicts absent in egg-laying species. With viviparity, conflict can arise between: mothers and embryos; sibling embryos in the (...) womb, and maternal and paternal genomes within individual embryos. Such intra- and intergenomic conflicts result in perpetual antagonistic coevolution, thereby accelerating interpopulation postzygotic isolation. In addition, by generating intrapopulation genetic incompatibility, viviparity-driven conflict favors polyandry and limits the potential for precopulatory divergence. Mammalian diversification is characterized by rapid evolution of incompatible feto-maternal interactions, asymmetrical postzygotic isolation, disproportionate effects of genomically-imprinted genes, and “F2 hybrid enhancement.” The viviparity-driven conflict hypothesis provides a parsimonious explanation for these patterns in mammalian evolution. BioEssays 22:938–946, 2000. © 2000 John Wiley & Sons, Inc. (shrink)

This book discusses the development of Edward Tolman's purposive behaviourism from the 1920s to the 1950s, highlighting the tension between his references to cognitive processes and the dominant behaviourist trends. It shows how Tolman incorporated concepts from European scholars, including Egon Brunswik and the Gestalt psychologists, to justify a more purposive form of behaviourism and how the theory evolved in response to the criticisms of his contemporaries. The manuscript also discusses Tolman's political activities, culminating in his role in the California (...) loyalty oath controversy in the 1950s. Tolman was involved in a number of progressive causes during his lifetime, activities that drew the attention of both state legislators in California and the Federal Bureau of Investigation. It treats Tolman's theoretical and political activities as emanating from the same source, a desire to understand the learning process in a scientific manner and to apply these concepts to improve the human condition. (shrink)

In this article, I respond to David McIvor’s and Lars Rensmann’s discussion of my recent book, The Politics of Repressed Guilt: The Tragedy of Austrian Silence (2018, Edinburgh University Press). Both invited me to clarify my use of Arendt in my conception of embodied reflective judgment. I argue for a stronger connection between judgment and emotions than Arendt because one can effectively shut down critical thinking if one uses defense mechanisms to repress feelings of guilt. In response to McIvor, (...) I discuss the idea of the “subject-in-outline” and “embodied reflective spaces” to overcome the guilt/defense complex to engender a reparative politics of justice. Finally, in response to Rensmann, I point out that the lingering culture of repressed guilt helps us explain the general conditions that contributed to the rise of the far and extremist right in Austria, which I develop further in my new book Analyzing the Far Right. (shrink)

Despite the importance of linguistic disclosure for philosophical hermeneutics there has been a conspicuous lack of attention to the question of how linguistic disclosure actually works. I examine the mechanics of disclosure by drawing on Gadamer’s philosophical hermeneutics as well as Ricoeur’s concept of translation and his theory of metaphor. My claim is that the background horizon of the unsaid that differs between languages enables each to disclose different things. This situation underscores the importance of engaging in East-West comparative philosophy, (...) of philosophizing across what Ricoeur calls the radical “fold” (pli) in what can be thought and experienced. (shrink)

David Miller is the foremost exponent of the purist critical rationalist doctrine and here presents his mature views, discussing the role that logic and argument play in the growth of knowledge, criticizing the common understanding of argument as an instrument of justification, persuasion or discovery and instead advocating the critical rationalist view that only criticism matters. Miller patiently and thoroughly undoes the damage done by those writers who attack critical rationalism by invoking the sterile mythology of induction and justification (...) that it seeks to sweep away. In addition his new material on the debate on verisimilitude is essential reading for all working in this field. (shrink)

Paul Virilio passed away on the 10th of September 2018. This article surveys his considerable legacy to cultural theory in order to locate a largely dormant contribution to questions of moral respo...

This paper attempts to reconcile two ideas that seem fundamentally opposed to one another: the reality of the self and the doctrine of no-self. Buddhism offers a form of spiritual equanimity that turns on the denial of a self. Nonetheless, there seem to be good reasons to hold onto the reality of the self. The existence of a self enables us to account for praise and blame, the hopes for oneself that motivate actions, and attachments to the selves of others (...) in bonds of love and affection. I show how it may be possible to reconcile the reality of the self with a particular interpretation of the no-self doctrine by engaging with the work of thinkers from the phenomenological tradition such as Merleau-Ponty, Zahavi, Gallagher, and Petitmengin. (shrink)

This dissertation examines Nietzsche's enigmatic concept of the Ubermensch. Many endeavors have been made to elucidate this term and all have confronted certain problematic areas concerning the Ubermensch. First, there are very few direct references to the term, and this applies not only to the published works but also Nietzsche's notes. Secondly, and more importantly, whenever Nietzsche does comment on the Ubermensch he does so with a vagueness that always leaves one puzzled concerning the concept. What results is a questioning (...) of the reasons for this lack of clarity: does it derive from the concept itself or from an inability on Nietzsche's part to expound on the Ubermensch? ;In attempting to answer this question, Nietzsche's relation to Dionysus is examined since he suggests that his entire philosophy is a result of a Dionysian Experience of man and existence, and not a Socratic experience. What is contrasted are two perspectives on existence: the Socratic which is grounded in the Greek term , and the Dionysian which is based on . Both of these perspectives offer a corresponding telos in correlation to their experiences of man and existence. The Socratic, which Nietzsche presents as the major influence on Western philosophy, seeks a telos which corresponds to its desire for , a telos of an Eternal nature. The Dionysian perspective, on the other hand, recognizing the Primordial Unity of existence and the aesthetic nature of man seeks a telos which complements a non-metaphysical existence; a telos termed by Nietzsche the Ubermensch. ;From these proceeding I conclude that the Ubermensch is necessarily vague as it is a non-descript term based on aesthetic projection rather than Socratic . The Ubermensch is a Dionysian telos that represents an ability to project a future derived out of the process of Uberwindung rather than a definitive, descriptive telos that would be universal for all men. Hence, the Ubermensch must remain amorphous for to clarify it once and for all would be to Socratically project in Error. (shrink)

Introduction -- The origins of Western law -- Progress and/or decline? -- The path of reductive neurolaw -- Method in theology and science -- Paleo-law : have we always been human? -- Towards a philosophical critique of neurolaw -- Mind, law, theology -- The soul of the law -- Law, violence, and original sin -- Conclusion.

This paper is a combination of a grandfather's musings over his grandson's drawings, combined with a reconsideration of hermeneutics as an early childhood educational theory.

Causation is important when considering how an organism maintains health, why disease arises in a healthy person, and how one may intervene to change the course of a disease. This paper explores the form of causative relationships in health, disease and intervention, with particular regard to the pathological and biopsychosocial models. Consistent with the philosophical view of dispositionalism, we believe that objects are the fundamental relata of causation. By accepting the broad scope of the biopsychosocial model, we argue that psychological (...) and social constructs be considered objects. We think that this 'biopsychosocial dispositionalism' offers the flexibility required to describe causation throughout health, disease and intervention pathways. When constructing mechanistic chains to describe causative pathways, we argue that an object will causally connect with others through actions; transfers of energy from one object to another, initiated by the manifestation of one or more dispositional property. Finally, our analysis of causative interactions utilises the concept that a common form of interaction exists between disease and intervention pathways. This common form will always be an object, but the mode of interaction will vary with each disease. We describe how intervention may act through objects being shared between converging mechanistic chains, or through the removal and/or insertion of objects in such chains. We believe that this analysis provides novel insight to the forms of causative transactions that can occur. In addition, we hope that the findings of this analysis represent the first step towards developing a framework for appraising the composition of mechanistic theories. (shrink)

Substantial urban growth fueled by a strong economy often results in heavy traffic thus making streets less hospitable. Traffic calming is one response to the pervasiveness of the automobile. The issues concern built environments and involve multiple actors reflecting different interests. The issues are rarely technical and involve combinations of behavior, social structure, and differential resources. Traffic calming takes many forms by attempting to serve many purposes. It is complex and confusing and is used by different people with different agendas. (...) Traffic calming is not about applying techniques. It is a mindset. We must change both our perceptions and our behaviors. Instead of focusing on end-of-pipe solutions and on things, we must shift attention to the processes that generate things. Trying to accommodate more and more traffic is not the answer. Transportation is a means, not an end. What we are looking at is more people calming than traffic calming. (shrink)

The interest in and enthusiasm for urban agriculture (UA) in urban communities, the non-profit sector, and governmental institutions has grown exponentially over the past decade. Part of the appeal of UA is its potential to improve the civic health of a community, advancing what some call food democracy. Yet despite the increasing presence of the language of civic agriculture or food democracy, UA organizations and practitioners often still focus on practical, shorter-term projects in an effort both to increase local involvement (...) and to attract funding from groups focused on quantifiable deliverables. As such, it seems difficult to move beyond the rhetoric of food democracy towards significant forms of popular participation and deliberation within particular communities. In this paper we provide a theoretical framework—deep democracy—that helps to contextualize nascent attempts at civic agriculture or food democracy within a broader struggle for democratic practices and relationships. We argue that urban agriculture efforts are well positioned to help citizens cultivate lasting relationships across lines of difference and amidst significant power differentials—relationships that could form the basis of a community’s collective capacity to shape its future. We analyze the theory of deep democracy through recent experiences with UA in Denver, Colorado, and we identify ways in which UA can extend its reach and impact by focusing more consciously on its political or civic potential. (shrink)

This book explores the way that human symbolic abilities have precipitated the colonisation and replacement of the natural world by the industrial order, transforming human character and experience.

They live in a world swirling in mist and darkness¿.Their mission is to tempt, tease, and seduce as they mesmerize us with their promise of taking our desires to the ultimate limit Dark Obsession For three centuries, Benjamin Bartlett¿s desire for blood¿and for the woman who granted him eternity¿has consumed him. But when he discovers a group of four people taking refuge in his home after their van breaks down, he¿s immediately drawn to Star Reid¿and soon she drives him over (...) the edge in a white-hot lust that won¿t be denied Blood Lust Vampire Christopher Marsh has searched for years for the talisman that could make him mortal again and give him the chance to fall in love. On the archeological dig he¿s supervising, beautiful professor Nicole Stephenson reminds him daily of what he wants but can¿t have. But when he abandons all control and gives in to his explosive desires, his quest takes on more urgency¿for he can¿t lose the woman he¿s been waiting so long for. (shrink)

While a number of classical pragmatists crafted their philosophies in conjunction with a careful study of Hegel's works, others saw their philosophies emerge in antagonism with proponents of Hegel. In this paper, we offer an instance of the latter case. Namely, we show that the impetus for Charles S. Peirce's early articulation and avowal of realism (the claim that some generals are real) was William Torrey Harris's claim that the formal laws of logic lacked universal validity. According to Harris, the (...) leading representative of Hegelism in the United States, the universal validity of the laws of logic rested on a nominalistic metaphysics that a Hegelian-realism showed to be false. In response to this charge, we articulate how Peirce's attempt to prove the universal validity of the laws of logic resulted in avowing a realism that differed from both nominalism and Harris's Hegelian-realism. (shrink)

This essay explains the difference between scholarly teachers and scholars of teaching and learning and provides a taxonomy of several research methodologies of scholars of teaching and learning in the field of philosophy.